To address these important questions, in the present work we used the low density lipoprotein receptor knockout (Ldlr−/−) mouse model of atherosclerosis transplanted with bone marrow from mice with macrophage-specific loss of TRPC3 (MacTrpc3−/−/Ldlr−/−) or control Ldlr−/− animals and examined the characteristics of advanced atherosclerotic lesions (14 weeks on high fat diet). Here, TRPC3 is linked to atherosclerosis.