Entero/Goblets (OT_NMF3), associated with the CIMP-High methylation pattern (Supplementary Fig. 10), had strong features of epithelial enterocytes, entero-endocrine and goblets cells, carbonate dehydratase activity, and higher levels of AGR2, known to promote adenocarcinomas growth33 (Supplementary Fig. 9). This evidence concerns the gene AGR2 and adenocarcinoma.