Resistance to cetuximab was also associated with expression of REG4, and featured strong epithelial (P=2 × 10−9), as well as developmental (P=1 × 10−5) signatures whereas sensitive tumours featured expression of MYC, JUN and E2F5, and of previously reported markers of cetuximab sensitivity CEACAM7 and EREG46, 56. This evidence concerns the gene JUN and neoplasm.