Since Lyden et al demonstrated for the first time that impaired recruitment of bone marrow-derived endothelial and hematopoietic precursor cells can effectively block tumour angiogenesis and tumour growth36, other bone marrow cells with tumour-promoting functions, for example CD11b+/Gr1+ bone marrow-derived myeloid cells, CXCR6-expressing bone marrow mesenchymal stem cells and CD13+ myeloid cells, have been identified37, 38, 39. This evidence concerns the gene CXCR6 and neoplasm.