In addition, pre-treatment of lung cell preparations with anti-CXCL5 neutralizing antibody or blockade of its receptor CXCR2 on ESCC cells abrogated the enhanced invasion of ESCC cells attracted by the lung preparations from mice bearing Id1-expressing tumours (Fig. 8e). The gene discussed is CXCL5; the disease is esophageal squamous cell carcinoma.