Mutations in fumarate hydratase (FH), succinate dehydrogenase﻿ ﻿(SDH)﻿﻿, and IDH1 and IDH2 are associated to specific human neoplasms that hence accumulate succinate, fumarate, and (R)-2-HG, respectively, all conveying broad oncogenic signals [75]. This evidence concerns the gene FH and neoplasm.