Reusch et al. designed a Tandab-based anti-CD16A × CD30 bispecific tetravalent fragment and found that this format is better than normal monoclonal anti-CD30 IgG, optimized monoclonal anti-CD30 IgG for FcγR binding, and diabody (bispecific and bivalent anti-CD16A and anti-CD30) formats in triggering NK cell lysis of Hodgkin lymphoma cells (CD30 as the antigen) (95, 96). Here, TNFRSF8 is linked to Hodgkins lymphoma.