ERBB2 and breast cancer: The strategy was applied to either Fc/single-chain Fv-Fc fusion (scFv-Fc) or scFv-Fc formats utilizing two different CH3 domains favoring heterodimer formation to generate CD16 × HER2 bispecific, which exhibited improved antitumor attributes against the breast cancer cell line SKBr3 in the presence of CD16+ natural killer (NK) cells from human peripheral blood mononuclear cells (PBMCs) (54).