A dual targeting CD3 × HER2 bispecific IgG1 was also constructed and showed a great enhancement in the T cell-mediated cytotoxicity against breast adenocarcinoma cells (AU565) in comparison to control antibody and in vivo tumor growth inhibition in an adoptive transfer xenograft model of gastric carcinoma with freshly prepared human PBMCs (56). Here, ERBB2 is linked to neoplasm.