The Tyk2 gene displays many different SNPs in the human population, and GWAS studies have linked mutations in Tyk2 to autoimmune diseases like systemic lupus erythematosus, multiple sclerosis, Crohn’s disease, psoriasis, type I diabetes, endometriosis-related infertility, primary biliary cirrhosis, and rheumatoid arthritis (22–25, 57–68). This evidence concerns the gene TYK2 and Crohn disease.