We also observed the positive correlation between 4-HNE protein adduct and 8-isoP in parotid glands of HFD-IR rats and plasma HOMA-IR, which may suggest that only parotid lipid peroxidation products concentration increase as a function of insulin resistance, whereas parotid protein carbonyls, 8-OHdG and submandibular lipid peroxidation products are independent of insulin sensitivity. The gene discussed is INS; the disease is Insulin resistance.