Next, using the same clustering analysis of the three subgroups (liver cirrhosis [LC], well-differentiated HCC [Edmondson grade I/II], and poorly-differentiated HCC [Edmondson grade III/IV]), we found that OIP5 expression was significantly higher in GI/II HCC than in LC, and was higher in GIII/IV HCC than in GI/II HCC, implicating upregulation of OIP5 in HCC progression. This evidence concerns the gene OIP5 and hepatocellular carcinoma.