Our previous study of xenograft colon tumors established that oncogenic Wnt signals directly activate PDK1 gene transcription as well as other glycolysis‐connected gene targets including the lactate transporter MCT1 (SLC16A1) (Pate et al, 2014; Sprowl‐Tanio et al, 2016). Here, PDK1 is linked to colonic neoplasm.