While a regular spotted array is not apparent in primary tumors like it is in xenografts, the heterogeneous pattern of clusters of cells with high glycolysis and high LEF‐1 in the epithelial portion of the tumor suggests that although xenograft tumors are artificial and have a different microenvironment, understanding the mechanisms underlying the observed spatial patterning in xenograft tumors can provide insight into the forces that create nongenetic heterogeneity in primary human colon tumors. Here, LEF1 is linked to colonic neoplasm.