INS and type 2 diabetes mellitus: The role of intestinal insulin resistance in the pathology of type 2 diabetes is unclear; however, it has been suggested that intestinal insulin resistance leads to abnormalities in the signaling mechanism responsible for the GLUT2-mediated GU in the small intestine, particularly in the jejunum, leading to increased transepithelial or lumen to blood glucose exchange, causing hyperglycemia (3).