The role of intestinal insulin resistance in the pathology of type 2 diabetes is unclear; however, it has been suggested that intestinal insulin resistance leads to abnormalities in the signaling mechanism responsible for the GLUT2-mediated GU in the small intestine, particularly in the jejunum, leading to increased transepithelial or lumen to blood glucose exchange, causing hyperglycemia (3). This evidence concerns the gene INS and Insulin resistance.