Indeed, (i) while both CYFIP1 and CYFIP2 interact with FMRP, only CYFIP2 interacts with FXR1P and FXR2P, the two paralogs and interactors of FMRP (Schenck et al., 2001); (ii) the expression of the two proteins appears differently modulated in different brain regions during post-natal brain development, while the three FXR proteins have the same expression pattern during development (Bonaccorso et al., 2015); (iii) depletion of CYFIP1 in epithelial cancer cells interferes with the morphology of the cells and induces invasion (Silva et al., 2009). The gene discussed is NR1H4; the disease is cancer.