Moreover, TRPC-1 protein expression was significantly lower in SSc-MVECs than in H-MVECs (p = 0.0013), while protein levels of VEGFR-2 and VEGF165b were both significantly higher in SSc-MVECs compared to H-MVECs (p = 0.026 and p = 0.0001, respectively) (Fig. 6d, e, f). The gene discussed is TRPC1; the disease is systemic sclerosis.