The trial will also provide evidence for the effect of vitamin D3 supplementation on a wide range of secondary outcomes including: CD4 T cell reconstitution, non-pulmonary TB comorbidities and complications associated with HIV and/or ART, bone health, immunologic biomarkers, weight gain, depression and anxiety, physical activity, and incidence of hypercalcemia. The gene discussed is CD4; the disease is hypercalcemia disease.