To further analyze the characteristics of CD19+CD24−CD38hi plasmablasts/plasma cells, we collected PBMCs from 15 newly diagnosed patients with IgG4-RD, and the following B cell subsets were sorted by flow cytometry: Bregs (CD19+CD24hiCD38hi), memory B cells (CD19+CD24+CD38−), naïve B cells (CD19+CD24intCD38int), and plasmablasts/plasma cells (CD19+CD24−CD38hi). The gene discussed is CD38; the disease is immunoglobulin G4-related sclerosing disease.