Aberrant PI3K/Akt/mTOR signaling is also seen in cells with FGFR1 overexpression and amplification [26], and response to the PI3K inhibitor alpelisib is reduced in ER+/PIK3CA-mutant breast cancer cells that overexpress FGFR1 [35]. The gene discussed is PIK3CA; the disease is breast carcinoma.