Although they are reported to be quantitatively and functionally altered in patients with active RA (reduction of their capacity to induce both Treg from CD4+ and prevent the conversion of Treg into Th17 cells) [30, 31], a recent report observed that a high baseline level of Breg appeared to be predictive of a clinical European League Against Rheumatism (EULAR) response at 3 months upon anti-TNF treatment [25]. This evidence concerns the gene TNF and rheumatoid arthritis.