AGO1 and viral infectious disease: AGO1 and AGO18 participate in the defense against Rice stripe virus (RSV, genus Tenuivirus, unassigned family) and Rice dwarf phytoreovirus (RDV, genus Phytoreovirus, family Reoviridae), wherein AGO1 is the direct antiviral effector, while AGO18, induced upon virus infection, combines with miR168 to sequester the down regulation of AGO1 by miR168 and thus confers a broad-spectrum antivirus resistance [24].