BNP levels increased with age (r = 0.40; p = 0.003), were higher in patients with CKD than in those without (43.1 [IQR 22.1–98.5] versus 12.5 [IQR 10.0–23.0] pg/ml; p = 0.0022) and were inversely correlated with eGFR (r = −0.45; p < 0.001). This evidence concerns the gene NPPB and chronic kidney disease.