Upregulation of survivin is mediated by multiple signaling pathways and by the tumor microenvironment including PI3K, MAPK, STAT3, Wnt/-catenin, hypoxia, angiogenesis, and NF-kβ signaling pathways [53, 76–80], hence may serve as an important target for leukemia therapy. Here, STAT3 is linked to neoplasm.