Some previous studies reported that caspase-3 could enhance the intrinsic apoptotic pathway in a positive feedback loop fashion in several cell lines, such as MCF-7 cells [55,56], DU145 prostate cancer cells [57,58], Hela cells [59], T leukemia cells [60] and other’s cell lines [61–63]. Here, CASP3 is linked to Familial prostate cancer.