ALOX15 and chronic obstructive pulmonary disease: The 15-LOX-1 pathway has been demonstrated to generate eoxines in eosinophils, mast cells, and nasal polyps from allergic subjects, indicating that inhibition of 15-LOX-1 might be an attractive target for the treatment of inflammatory respiratory disorders such as asthma, rhinitis, and chronic obstructive pulmonary disease (COPD) in humans.