DHRS11 and neoplasm: Taking into account the fact that LAPC-4 cells are derived from a patient who went through androgen-deprivation therapy [20, 38], it is possible that in the model we used for our xenograft experiment (Fig 4), the presence and activity of 17β-HSD15 and/or DHRS11 could have prevented us to see the expected tumor regression in the group treated with RM-532-105.