In adiposity, excess secretion of various pro-inflammatory cytokines, chemokines, and proteases, such as TNF-α, IL-6, MCP-1, leptin, and PAI-1, by infiltrating macrophages and T cells around the adipose tissue, leads to endothelial dysfunction, oxidative stress, and inflammation activation [19, 33]. Here, CCL2 is linked to endothelial dysfunction.