Darpp-32 plays a key role in integrating neurotransmitter and neuromodulator signals in the GABAergic medium-size spiny neurons in the striatum, in particular in response to dopamine and glutamate and therefore upregulating its expression may alleviate disturbances in dopamine transmission that contribute to motor deficits in HD mice [29]. This evidence concerns the gene PPP1R1B and Huntington disease.