In a proposed new approach to prenatal care, screening using a combination of maternal risk factors, mean arterial pressure, uterine artery Doppler, and maternal serum biomarkers (pregnancy-associated plasma protein-A and placental growth factor) can identify up to 95% of cases with early onset of preeclampsia for a false-positive rate of 10% [46, 47]. The gene discussed is PGF; the disease is preeclampsia.