Genetic polymorphisms at the 5′ UTR promoter region of SLC6A3 have been proposed to be functional and known to alter transcriptional activity [12], and that these variants found in the promoter region may have a role in several psychiatric disorders, including attention deficit-hyperactivity disorder [37], bipolar disorder [38], and schizophrenia [39]. The gene discussed is SLC6A3; the disease is bipolar disorder.