IL10 and psoriasis: There are reports of patients developing psoriasis after rituximab therapy, but there are also cases whose cutaneous lesions and psoriatic arthritis partially improved after taking rituximab.26,27 Interleukin-10-secreting regulatory B cells mediate the suppression of autoimmune and inflammatory diseases by inhibiting Th1 and Th2 cytokine polarization, antigen presentation, and proinflammatory cytokine production by monocytes and macrophages.