BRCA1 and benign epithelial neoplasm: It is evident that median HE4 concentrations were the highest for ovarian cancers (409.75) followed by endometrial cancers (97.3), other gynecological cancers (58.15), noncancer ovarian cysts (47.45), benign epithelial tumors (47.27), endometriosis (46.5), myomas (44.65), and BRCA1 mutation carriers (38.25).