Statistically significant correlations between the serum levels of CA125 and HE4 were observed in the ovarian cancer group (r = 0.3547,  P = 0.0001), endometrial cancer group (r = 0.7986,  P = 0.0011), and benign epithelial tumor group (r = 0.3629, P = 0.0349). The gene discussed is WFDC2; the disease is benign epithelial neoplasm.