The effects of C-phycocyanin on COX-2 [64, 65] and iNOS [64] were also confirmed in animals, where a decrease of the proinflammatory TNF-α expression in the carragenan-induced rat paw [64] and of the TNF-α and interleukin-1β (IL-1β) expression in the cochlea and inferior colliculus after salicylate-induced tinnitus in mice was observed [65]. The gene discussed is TNF; the disease is Tinnitus.