The increasing recognition of the dynamic entity of ANGPTL4 and its multifunctional role in different metabolic and nonmetabolic pathways, the expression network linking PPARs isoform to this angiopoietin-like protein, together with the recent evidences of involvement of PPAR in cancer, led to do some significant speculations on the potential molecular cross talk between these molecules, lipid metabolism, and cancer [149]. The gene discussed is ANGPTL4; the disease is cancer.