In hepatocellular carcinoma cells, ANGPTL4 also favors transendothelial migration and metastasis, through upregulation of vascular cell adhesion molecule-1 (VCAM-1) on endothelial cells, and stimulates the VCAM-1/integrin β1 signaling pathway, facilitating the cancer cell transendothelial extravasation to develop distant metastasis [124]. Here, ANGPTL4 is linked to cancer.