In fact, we previously reported that MCM7 depletion could prevent cyclin D1 expression in untransformed human dermal fibroblasts.34 In this study, as expected, we also found that knockdown of MCM7 significantly inhibited cyclin D1 expression in HCC cell lines, indicating an essential role of MCM7 in regulation of cell cycle. Here, CCND1 is linked to hepatocellular carcinoma.