For example, MCM7, a replication factor that binds to DNA double strand at replication origins in the late G1 phase and forms the pre-RC complex during cell cycle progression,27 is highly expressed in various cancers and can be used as a potential proliferation marker.17, 21, 28, 29 Zhou et al.20 reported that MCM7 was positive in 42 of 87 HCC tumors (48.2%) but negative in all noncancerous tissue. This evidence concerns the gene MCM7 and hepatocellular carcinoma.