BRG1 is mutated or aberrantly expressed in some kinds of tumors.28 In our previous study, we observed that BRG1 expression was reduced in metastatic tissues of CRC, indicating that BRG1 expression dynamically fluctuates by tumor progression.6 In this study, we found that BRG1 was inversely correlated with senescence in CRC cell lines in classic senescent cell models. The gene discussed is SMARCA4; the disease is neoplasm.