SMARCA4 and colorectal carcinoma: Cellular senescence is characterized by upregulated SA-β-gal activity, inhibited cell proliferation, cell cycle arrest, and formation of SAHF.13 A BRG1 KD cell model was produced by transfecting CRC cells with BRG1 shRNA (sh-BRG1) to further investigate the function and mechanism of BRG1 in senescence.