P53 has an important role in cell senescence; acetylated p53 presents longer half-life and enhanced ability to activate p21 transcription, a master regulator of senescence.17, 18, 19 The P53/p21 pathway is a putative target for cancer therapy because of its significant effect on senescence in colon cancer, melanoma, glioma, and liver cancer.20, 21, 22, 23. The gene discussed is TP53; the disease is melanoma.