SIRT1 downregulates p53 expression at a post-transcriptional level by deacetylating p53 at K382.32, 33 Thus, SIRT1 executes its senescence regulation by inhibiting the p53/p21 pathway and subsequently promoting tumorgenesis.34 Cheng et al.35 reported that SIRT1 is highly expressed in CRC and inversely correlated with CRC prognosis, indicating that SIRT1 is a novel oncogene that induces CRC tumorigenesis. Here, TP53 is linked to colorectal carcinoma.