P53 has an important role in cell senescence; acetylated p53 presents longer half-life and enhanced ability to activate p21 transcription, a master regulator of senescence.17, 18, 19 The P53/p21 pathway is a putative target for cancer therapy because of its significant effect on senescence in colon cancer, melanoma, glioma, and liver cancer.20, 21, 22, 23. This evidence concerns the gene TP53 and colonic neoplasm.