This result conforms to the earlier reports of Hsu et al.29 and Naidu et al.30 but is opposite with the results in rat mesenchymal stem cell and retinoblastoma.4 A universal conclusion regarding the effect of BRG1 on cell senescence is difficult to achieve because cell models in these previous studies ranged from fibroblasts to stem cells. The gene discussed is SMARCA4; the disease is retinoblastoma.