MAP3K7 and skin papilloma: Epidermal-specific inducible Tak1 deletion can induce tumor regression in skin papilloma but does not cause observable injury in the normal skin.9 Treatment with a selective TAK1 inhibitor 5z-7oxozeanol38 effectively blocks tumor growth without overt toxicity.52 Thus, although inhibition of TAK1 must be entertained with considerable caution, regulated inhibition of TAK1 may be potentially useful to selectively kill macrophages without affecting adaptive immunity in certain contexts.