SQSTM1 and soft tissue sarcoma: Tenovin-6 has recently been shown to impair the autophagy pathway by increasing the levels of LC3-II (lipidated form of LC3) and/or SQSTM1/p62 in CLL cells7, 8 and pediatric soft tissue sarcoma cells.15 However, it is unclear whether tenovin-6 has a general effect on autophagy on other types of cells.