Several unrelated signaling pathways were suggested to be inhibited by luteolin including Akt-Gsk-cyclin D pathway in nasopharyngeal carcinoma, PKC and c-Src pathways in UVB-induced skin cancer and Nrf2 signaling in lung cancer.22, 24, 25 These findings raised the question whether luteolin indeed targets different pathways in different cells, or there is a common mechanism shared by various luteolin-sensitive cells. This evidence concerns the gene PRRT2 and skin cancer.