IL-6 secreted from microglia contributes to the inflammatory reaction in PD.23, 24, 25 Here we found that rapamycin did not significantly change the expression of IL-6, IL-6R, or gp130 in MPP+-treated microglial BV2 cells (P>0.05) (Figure 5c, first 3 rows). Here, IL6 is linked to Parkinson disease.