Consistent with these findings, regulation of GLT via Nedd4-2 has been reported in alternative neurodegenerative disease models.54, 55, 56 Our recent unpublished data also suggest that Nedd4-2 knockdown ameliorates movement disorders and increases TH expression in PD mice via decreasing GLT ubiquitination. This evidence concerns the gene NEDD4L and neurodegenerative disease.