In most instances, NF1 and DAB2IP behave as the classical tumor-suppressor genes.12 For example, our and other previous studies have demonstrated that DAB2IP has distinct cellular functions such as concurrently modulating different oncogenic pathways associated with cell proliferation, survival, apoptosis and metastasis.22, 23, 24 However, the expression and functions of RASAL2 in different cancer types remain largely unknown. The gene discussed is RASAL2; the disease is cancer.