Current studies have reported that cancer stemness and EMT always appear coincidently, and EMT endows cells with a more CSC-like and mesenchymal phenotype.19 Indeed, 5637 cells revealed a cobblestone-like morphology; however, RASAL2-deficient 5637 cells displayed an elongated fibroblastoid appearance, as well as increased cell migration and invasion in vitro (Figures 3a, **P<0.01, ***P<0.001). This evidence concerns the gene RASAL2 and cancer.