LncRNAs have recently been identified as novel regulators of transcriptional and epigenetic networks.27 HOTAIR, a classic trans-acting lncRNA, was found to be abnormally upregulated in several tumors, including hepatocellular carcinoma, colorectal cancers, pancreatic cancers, breast cancers, bladder cancers, cervical cancers and osteosarcoma.7, 37, 38, 39, 40, 41, 42 Many studies have revealed that HOTAIR acts as a potential antitumor target. The gene discussed is HOTAIR; the disease is osteosarcoma.