In this study, we found that the level of miRNA miR-454-3p increased after HOTAIR knockdown, and its upregulation repressed the translation of its target, the transcription factor signal transducer and activator of transcription 3 (Stat3), which has an important role in tumor proliferation, and another target, autophagy-related gene 12 (ATG12), which is an autophagy marker that is significant for the resistance to apoptosis in many types of tumors. The gene discussed is STAT3; the disease is neoplasm.