Autophagy can either inhibit or promote tumor cell growth in different cellular contexts.28, 29, 30, 31 Given that manipulating autophagy may improve the efficacy of anticancer therapeutics,32, 33 we were eager to determine whether the HOTAIR knockdown-induced inhibition of autophagy in chondrosarcoma favored cell survival or cell death. The gene discussed is HOTAIR; the disease is chondrosarcoma.