The immuno-reactivity variations in the tumor of animals sacrificed after evaluation of anti-tumor efficacy were perceived in contradiction of the apoptotic markers, caspase-3 and PARP (cleaved poly(ADP-ribose) polymerase), angiogenesis marker, PECAM-1 (platelet endothelial cell adhesion molecule 1) or CD31 and tumor cell proliferation marker, Ki-67 (Ramasamy et al., 2015; Tran et al., 2015; Poudel et al., 2016). Here, CASP3 is linked to neoplasm.