PCK2 and Insulin resistance: To assess the effect on insulin resistance in liver, we analyzed the mRNA levels of ER stress-responsive genes as well as gluconeogenic genes including peroxisome proliferator activated receptor γ coactivator-1α (PGC-1α), phosphoenolpyruvate carboxykinase (PEPCK) and glucose 6-phosphatase (G6Pase) (Salvado et al., 2015).