IREB2 and lung carcinoma: rs2568494, previously reported to be associated with COPD33, 34, is an A/G variant in IREB2. This SNP is included in the IREB2 AAAT haplotype (rs2568494, rs2656069, rs10851906, rs13180) that has recently been associated with lung cancer risk (OR  =  1.5)35.