We demonstrate here for the first time that trappin-2 (T-2), a cationic antimicrobial/anti-inflammatory agent29, 30, 31, 32, 43 is an efficient inhibitor of malaria parasite growth and a critical regulator of the pathophysiological consequences of asexual blood stage parasite infection in a rodent model of ECM. This evidence concerns the gene PI3 and biological process involved in symbiotic interaction.