CAV1 and obesity due to melanocortin 4 receptor deficiency: Finally, our data regarding the role of miR-204 in downregulating vascular Cav1 in a high-fat diet feeding model of obesity support studies showing that obesity in humans and in experimental models is associated with downregulation of Sirt123, 24, 25, 26 and Cav118, 27, and upregulation of miR-2047 in various tissues (Fig. 6).