Importantly, a single nucleotide polymorphism (SNP) in Cdh23 (753G > A, also called Ahl), which encodes for the essential HC tip link component Cadherin 23, has been previously reported to cause an increased susceptibility to both noise-induced and age-related hearing loss in several inbred mice strains, including C57BL/6J25, 26, 27, 28, 29. This evidence concerns the gene CDH23 and presbycusis.