NPPB and heart disorder: Despite some limitations of this study (we used high doses of natriuretic peptides, we didn’t measure plasma BNP levels and we detected a huge increase of cGMP in vivo), the identification of the signaling pathways by which BNP modulates the fate of the endogenous Sca-1+ cells is of high importance for optimizing further clinical use of the natriuretic peptides in patients suffering from heart diseases.