Other proposed EndMT drivers include Wnt/β-catenin signalling that is known to act synergistically with TGFβ to promote EndMT in endocardial cells and in cavernomas of Ccm3 deficient mice103, 111 and certain miRs such as: miR-20a that is down stream of FGF2 and targets TGFβR1 and R2 inhibiting EndMT57 and miR-21 that is induced by TGFβ signalling and promotes EndMT. This evidence concerns the gene TGFB1 and cavernous hemangioma.