In order to identify molecular determinants that could explain the differential, inhibitory/stimulatory, responses to BIM-23A760, expression levels of sst2/sst5/D2 were measured in GHomas and ACTHomas and the results were compared between “inhibited pituitary adenomas” and “stimulated pituitary adenomas”, based on the data of [Ca2+]i kinetics. The gene discussed is SSTR5; the disease is ACTH-producing pituitary gland adenoma.