However, it should be noted that, in line with both the stimulatory and inhibitory effects of BIM-23A760 observed on [Ca2+]i levels, we also observed that BIM-23A760 increased GH and ACTH release in individual cases of GHomas and ACTHomas, which suggest that there are different subpopulations of adenomas. This evidence concerns the gene POMC and ACTH-producing pituitary gland adenoma.