Analysis and comparison of the expression levels profile of D2 and sst2/sst5-subtypes in human GHomas and ACTHomas revealed that D2 and sst5 expression levels were significantly higher than sst2 in inhibited GHomas (Fig. 4A); whereas, sst5 levels were lower than those of D2 in stimulated GHomas. This evidence concerns the gene SSTR5 and ACTH-producing pituitary gland adenoma.