Our data indicate that BIM-23A760 inhibited [Ca2+]i levels in normal and tumoral pituitary cells; but increased [Ca2+]i levels in a population of GHomas, ACTHomas and NFPAs, demonstrating that BIM-23A760 directly acts on human pituitary adenomas and normal pituitary cells by activating [Ca2+]i levels. The gene discussed is BCL2L11; the disease is ACTH-producing pituitary gland adenoma.