LMO2 and acute lymphoblastic leukemia: To determine whether the 8-bp heterozygous insertion in the LMO2 locus confers enhancer activity, the insertion allele and the reference allele were cloned into enhancer reporter vectors, and these were transfected into Jurkat T-ALL cells; the results indicate that the insertion allele has significantly more enhancer activity than the reference allele (Fig. 4e, P<0.001, two-tailed Student's t-test).