PHLPP1 and malignant colon neoplasm: Importantly, our findings that PHLPP loss induced upregulation of glycolysis can be abolished by inhibition of Akt, dissociation of HK2 from the mitochondria or knockdown of HK2 indicate that PHLPP regulates glucose metabolism through a PHLPP/Akt/HK2 axis in colon cancer cells.