A number of those CAPs that can induce apoptosis in mammalian tumor cells have also been shown to trigger the caspase-3-dependent process of DNA fragmentation.25 These include buforin IIb,37 BMAP-28,20 epinecidin-113 and lactoferricin B.14,38 Consistent with the lack of caspase activity observed during this study, NaD1 failed to induce DNA laddering at any of the tested time points at subacute concentrations, further indicating that NaD1 does not mediate apoptosis in MM170 or Jurkat cells, under the conditions tested. Here, CASP3 is linked to neoplasm.