MT-ND1 and neoplasm: Furthermore, as the PIP2-binding agent, Neomycin, was able to inhibit significantly NaD1-mediated membrane permeabilization even at these lower concentrations over a 24 h period, it is likely that PIP2-mediated oligomerization and membrane disruption of tumor cells, as described previously by Poon et al.,17 can occur under these conditions.